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Index > Protein center > Loxl2(Gene name) > Rat
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  • Loxl2 (Gene name),
  • Lysyl oxidase homolog 2 (Protein name ),  LOXL2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Loxl2;
    Protein name:
    Lysyl oxidase homolog 2;
    Alternative:
    Lysyl oxidase-like protein 2;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Component of some chromatin repressor complex. Interacts with SNAI1.
    Function:
    Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
    Subcellular Location:
    Secreted Extracellular space Extracellular matrix Basement membrane Nucleus Chromosome Associated with chromatin (By similarity). It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.
    Protein Attributes:
    Sequence length:
    776
    Sequence:
    50:
    MEIPFGSCLY | SCLALLVLLP | SLSLAQYESW | PYQLQYPEYF | QQPPPEHHQH | 
    100:
    QVPSDVVKIQ | VRLAGQKRKH | NEGRVEVYYE | GQWGTVCDDD | FSIHAAHVVC | 
    150:
    REVGYVEAKS | WTASSSYGPG | EGPIWLDNIY | CTGKESTLAA | CSSNGWGVTD | 
    200:
    CKHPEDVGVV | CSEKRIPGFK | FDNSLINQIE | SLNIQVEDIR | IRPILSAFRH | 
    250:
    RKPVTEGYVE | VKEGKAWKQI | CDKHWTAKNS | HVVCGMFGFP | AEKTYNPKAY | 
    300:
    KTFASRRKLR | YWKFSMNCTG | TEAHISSCKL | GPPMFRDPVK | NATCENGQPA | 
    350:
    VVSCVPSQIF | SPDGPSRFRK | AYKPEQPLVR | LRGGAQVGEG | RVEVLKNGEW | 
    400:
    GTVCDDKWDL | VSASVVCREL | GFGTAKEAVT | GSRLGQGIGP | IHLNEVQCTG | 
    450:
    TEKSIIDCKL | NTESQGCNHE | EDAGVRCNIP | IMGFQKKVRL | NGGRNPYEGR | 
    500:
    VEVLTERNGS | LVWGNVCGQN | WGIVEAMVVC | RQLGLGFASN | AFQETWYWHG | 
    550:
    NIFANKVIMS | GVKCSGTELS | LAHCRHDEEV | VCPEGGVQYG | AGVACSETAP | 
    600:
    DLVLNAEIVQ | QTAYLEDRPM | ALLQCAMEEN | CLSASAVHTD | PTRGHRRLLR | 
    650:
    FSSQIHNNGQ | SDFRPKNGRH | AWIWHDCHRH | YHSMEVFTYY | DLLSLNGTKV | 
    700:
    AEGHKASFCL | EDTECEGDIQ | KSYECANFGE | QGITMGCWDM | YRHDIDCQWI | 
    750:
    DITDVPPGDY | LFQVVINPNY | EVPESDFSNN | IMKCRSRYDG | YRIWMYNCHV | 
    776:
    GGAFSEETEQ | KFEHFSGLLN | NQLSVQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Lysyl oxidase homolog 2
    Cat.:
    E14939h
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    MSDS:
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    96T
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    ELISA Kit for Rat Lysyl oxidase homolog 2
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Lysyl oxidase homolog 2
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Lysyl oxidase homolog 2
    Cat.:
    E14939r
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Lysyl oxidase homolog 2
    Cat.:
    E14939m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Lysyl oxidase homolog 2
    Cat.:
    U14939h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Lysyl oxidase homolog 2
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Lysyl oxidase homolog 2
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Lysyl oxidase homolog 2
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Lysyl oxidase homolog 2
    Cat.:
    U14939m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Lysyl oxidase homolog 2
    Polyclonal Antibody for Rat Lysyl oxidase homolog 2
    Polyclonal Antibody for Rat Lysyl oxidase homolog 2
    Polyclonal Antibody for Rat Lysyl oxidase homolog 2
    Polyclonal Antibody for Rat Lysyl oxidase homolog 2
    Monoclonal Antibody for Rat Lysyl oxidase homolog 2
    Monoclonal Antibody for Rat Lysyl oxidase homolog 2
    Monoclonal Antibody for Rat Lysyl oxidase homolog 2
    Monoclonal Antibody for Rat Lysyl oxidase homolog 2
    Monoclonal Antibody for Rat Lysyl oxidase homolog 2
    Protein for Rat Lysyl oxidase homolog 2
    Protein for Rat Lysyl oxidase homolog 2
    Protein for Rat Lysyl oxidase homolog 2
    Protein for Rat Lysyl oxidase homolog 2
    Protein for Rat Lysyl oxidase homolog 2

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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Heart.
    3. 3.
      "Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane."
      Bignon M. , Pichol-Thievend C. , Hardouin J. , Malbouyres M. , Brechot N. , Nasciutti L. , Barret A. , Teillon J. , Guillon E. , Etienne E. , Caron M. , Joubert-Caron R. , Monnot C. , Ruggiero F. , Muller L. , Germain S.
      Blood118:3979-3989(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
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